2022 Awardees
Kaid Harper
AbbVie
Carolyn Wei
Amgen
Martin Himmelbauer
Biogen
Emily Cherney
BMS
Maryll Geherty
BMS
John Roberts
Dow
Andrew DeAngelis
FMC
Allen Hong
Genetech
Terry Lebold
Janssen
Connor Martin
Janssen
Austin Smith
Loxo – Lilly
Yining Ji Chen
Merck
Eric Phillips
Merck
David Thaisrivongs
Merck
Janelle Sauvageau
NRC, Canada
Simone Bonazzi
Novartis
Hansnain Malik
Novartis
Dan Schmitt
Pfizer
2021 Awardees
Omar Ahmad
Blueprint
Christophe Allais
Pfizer
Matthew Beaver
Amgen
Raphaelle Berger
Merck
Alexander Buitrago-Santanilla
GSK
Ida Chen
Dow
Anne-Marie Dechert Schmitt
Pfizer
Amelie Dion
Merck/Pfizer
Anna Dunn
GSK
Candice Joe
BMS
Anais Jolit
AbbVie
Leo Joyce
Arrowhead
Carolyn Leverett
Pfizer
Xiaoli Liao
AbbVie
Brian Loy
Corteva Agriscience
Yu Lu
Lilly
Feng Peng
Merck
Vivek Rauniyar
Novartis
Chris Regens
Gilead
Troy Reynolds
AbbVie
Trevor Sherwood
BMS
Steven Silverman
Merck
Lauren Sirois
Genentech
Craig Stivala
Genentech
Shun Su
BMS
Benjamin Taft
Novartis
Dan Treitler
BMS
Tom Willumstad
Dow
Yun Zhang
AstraZeneca
2020 Awardees
Matthew Belowich
Dow
Lewis Acids as Highly Active Silanol Polycondensation Catalysts Affording Low Levels of Cyclosiloxanes
Tamas Benkovics
Merck
Innovation for the Synthesis of Diverse Nucleosides
Nick Desrosiers
Pfizer
Development of Difluoromethylation Methodologies for Large-Scale Processes
Anna Fryszkowska
Merck
Biocatalysis in the pharmaceutical industry – chemistry for tomorrow’s earth.
Chong Han
Genentech
Chemoselective, Stereocontrolled Cu-Catalyzed C-N Couplings Towards a Highly Potent mPI3Ka Inhibitor GDC-0077
Sebastien Monfette
Pfizer
Nickel catalysis: Novel ligands and reactions of practical importance to the pharmaceutical industry
Ryan Moslin
BMS
Inhibition of TYK2 via the Pseudokinase: The Discovery of Deucravacitinib
Jaclyn Murphy
DuPont
Development of new materials for electronic applications
Zack Oblak Oblak
GSK
The design and development of a manufacturing process for GSK’772
Martins Oderinde
BMS
Photocatalytic [2+2] Cycloaddition for Building Cyclobutane-Fused Three-Dimensional Molecular Complexity
Andrew Parsons
Amgen
Development of a commercial manufacturing process for an atropisomeric KRAS G12C inhibitor
Ryan Patman
Pfizer
Design and Synthesis of Carbonucleoside Inhibitors of PRMT5 for the Treatment of Cancer: A Desymmetrization Approach
David Pearson
Dow
Carbon-carbon centered radical initiators for polymerization of unsaturated monomers.
Christopher Plummer
Merck
Identification and Optimization of Positive Allosteric GPR40 Agonists for Diabetes
Danica Rankic
Pfizer
Strategies toward robust and scalable syntheses of α-pyrazolyl pyrrolidines
Mari Rosen
Dow
Chromium Catalysts with Phospholane Ligands for Ethylene Tetramerization
Janelle Steves
GSK
HTE in 3D: Implication of phosphine featurization methods on HTE design and analysis of reaction outcomes
Aimee Usera
Novartis
Ride of a lifetime: a novel half-life extension technology succeeding across chemical space
Jason Zbieg
Genentech
Discovery of a Chiral Amphiphilic Iridium Catalyst for Carbon- Heteroatom Bond Formation: Reactions of Amines, Anilines, Indoles and Other Various Nucleophiles.
2019 Awardees
Brad Bailey
Dow
Polyolefin catalysts for the production of ethylene-based fluids
Bryan Barton
Dow Dupont E&I
Shifting the oxidation pathways of polyethylene to provide carbonaceous species in high yield
Amanda Dombrowski
Abbvie
High-throughput reaction screening enabled by small scale solid dispensing
Shuzhi Dong
Merck
Discovery of MK-8153: ROMK inhibitor as new mechanism diuretic for hypertension and heart failure
Stephen Greszler
Abbvie
Impacting the pipeline through discovery synthesis groups: Cystic fibrosis, HCV, and immunology
Michael Harris
NovoNordisk
Development of PMC friendly approaches to the construction of synthetically challenging cyclopropane motifs
Josh Kaitz
Dupont
Rational design of organic materials for advanced microlithography
Jonrock Kong
Merck
Design and development of catalytic processes for the synthesis of antiviral agents EFdA (MK-8591) and vaniprevir (MK-7009)
Chad Lewis
Pfizer
Asymmetric atropisoinduction
David Marcoux
BMS
Rationally designed, conformationally constrained inverse agonists of ROR?t: Identification of a potent, selective series with biologic-like in vivo efficacy
Tricia May-Dracka
Biogen
Investigation of small molecule inhibitors of PLD for the treatment of ALS
Meredith McGowan
Merck
Discovery and evolution of potent and selective heme-displacing IDO1 inhibitors
Jordan Meier
NCI
New insights into acetylation & oncometabolism from chemoproteomics
Theo Michels
eFfector
Synthesis of bioactive flavagline analogues as inhibitors of cap-dependent translation: Discovery of eFT226
Erik Regalado
Merck
Universal chromatographic methods and fit for purpose workflows in the research and development of new pharmaceuticals
Benjamin Sherry
Merck
Process development in the pharmaceutical industry
Iulia Strambeau
GSK
Convergent synthesis of the NS5B inhibitor GSK8175 enabled by transition metal catalysis
Jenna Terebetski
Want to improve your (bio)performance? Take a closer look at the physical properties
Rubben Torella
Pfizer
Designing for bias: Computational methods to drive rational design of G-protein biased agonists
Joseph Tucker
Pfizer
High-throughput experimentation in flow: From screening to compound production
Steven Wisniewski
Bristol-Myers Squibb
Robust catalytic transformations: Value of mechanistic studies in process chemistry
Robert Wright
Dow
Organic molecules as forensic fuel markers
Ian Young
Genentech
Application of under-utilized transformations to the synthesis of pharmaceutically relevant molecules
2018 Awardees
Karla Bravo-Altamirano
Corteva Agriscience
Synthesis and bioactivity of carbohydrate-based macrocyclic picolinamide fungicides.
Alison Brewer
Pfizer
Design, development and scale-up of a homogeneous Chan-Lam coupling
Matthew Campbell
Merck
Herbicidal 2-aryl-1,2,3-triazoles
Benoit Cardinal-David
Abbvie
Flow chemistry: Impact on early process development
Chiol Chung
Genentech
Expedient synthesis of chiral tryptamines via a regioselective indole alkylation
Jamie McCabe Dunn
Merck
Vignettes in process chemistry spanning enabling discovery chemistry to manufacturing route development
Marie Gabrielle-Braun
Genentech
Discovery of GDC-0077: A highly selective inhibitor of PI3K-alpha that induces degradation of mutant-p110 alpha protein
Tom Greshock
Merck
Innovative chemistry enabling drug discovery: Leveraging new frontiers in organic synthesis to improve success rate
David Laitar
Dow
Boron- and copper-based TADF emitters: Synthesis, photochemical characterization and OLED device performance
Ricardo Lira
Pfizer
Preparation and optimization of macrocyclic peptide-like inhibitors for intravenous applications
Sheng Liu
Dow
Design and synthesis of high carbon content polymers via catalytic oxidative cross-coupling reactions for application in advanced manufacture
Michael Luzung
Bristol–Myers Squibb
Discovering innovative and impactful chemistry through external collaborations
Steven M. Mennen
Amgen
Integration of discovery and process development to deliver a high complexity BACE inhibitor
Joseph Pero
GlaxoSmithKline
Discovery of a novel class of TRPV4 antagonists and optimization with respect to LLE, oral PK properties and off-target activity
Angela Puchlopek-Dermenci
Pfizer
Commercial route development of a SMO inhibitor
Aaron Smith
Pfizer
Speed to clinic: The critical role of organic synthesis in medicinal chemistry.
2017 Awardees
Scott Bader
Pfizer
Synthesis of active pharmaceutical ingredients (APIs): Difficulties in the synthesis of the parts can be greater than that of the whole
Douglas Behenna
Pfizer
Discovery and early enablement of PF-06747775: A next generation irreversible inhibitor of mutant EGFR for the treatment of NSCLC.
Aaron Burns
Dart Neuroscience
Aldehyde Oxidase Metabolism in Drug Discovery
Vincent Chan
AbbVie
Development of a robust process for Venetoclax
Michael Demartino
GlaxoSmithKline
Next generation RET kinase inhibitor: Improved physicochemical and PK properties enhance local GI tissue distribution
Kevin Hesp
Pfizer
Synthesis of Photoreactive Chemical Probes through Late-Stage Heterocyclic C-H Functionalization of Unmodified Biologically Active Molecules
Xin Linghu
Genentech
Development of a practical synthesis of small molecule intermediate for THIOMAB-antibiotic conjugates (TACs)
Zhijian Liu
Merck
Asymmetric Hydrogen Bonding Catalysis for the Synthesis of Dihydroquinazoline-containing Antiviral, Letermovir
Ana Minatti
Amgen
Fueling the Alzheimer’s BACE1 Race with Genetic Insights and Cyclopropyloxazine BACE1 Inhibitors
Christian Nilewski
eFFECTOR Therapies
Design and synthesis of novel natural product-inspired eIF4A inhibitors
Thomas Pillow
Genentech
New Chemistries for Antibody-Drug Conjugates
Izzat Raheem
Merck
Discovery of 2-pyridinone aminals: A prodrug strategy to advance a second generation of HIV-1 integrase strand transfer inhibitors
Matthew Schiffler
Lilly
mPGES-1 Inhibitors from start to clinic
Eric Simmons
Bristol–Myers Squibb
Discovery, Development and Mechanistic Study of Catalytic Transformations for the Multi-Kilogram Scale Synthesis of Pharmaceutical Intermediates
Emile Velthuisen
GlaxoSmithKline
Design of Highly Potent Allosteric Integrase Inhibitors
Abbas Walji
Merck
New opportunities for synthetic chemistry to enable drug discovery: Discovery of [18F]MK-6240 a novel PET imaging agent for tau pathology
2016 Awardees
Robert Aversa
Novartis
ATR inhibitors for cancer: SBDD and mitigation of TDI
Haiming Zhang
Genentech
Practical processes to selective estrogen receptor degrader GDC-0810
Michael Schmidt
Bristol-Myers Squibb
Case studies in process research: Small molecules with big challenges
Hua Xu
Pfizer
Applications of sulfonyl fluorides in drug discovery and chemical biology
Erin P. Keaney
Novartis
Disruption of autophagy in vivo via selective Vps34 inhibitors
Eric C. Hansen
Pfizer
Mining pharmaceutical libraries for new ligands in nickel catalysis
Philip Fontaine
Dow Chemical
Discovery and development of molecular polyolefin catalysts
Hilary S. Eidam
GlaxoSmithKline
RET inhibitors for the treatment of irritable bowel syndrome
Christopher am Ende
Pfizer
Design and application of photoaffinity probes to investigate the mechanism of action of ?-secretase inhibitors and modulators
Joseph R. Martinelli
Eli Lilly
Evolution of a platform for aerobic processes
Malliga R. Iyer
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Synthetic approaches toward the design of multi-target compounds for the treatment of metabolic disorders and fibrosis
Anna V. Davis
Dow Chemical
Advances in the direct control of polyethylene oxide molecular weight
Mirlinda Biba
Merck
Chromatographic analysis and separation of short RNA oligonucleotides with novel liquid chromatography methods
Dennie S. Welch
AbbVie
Development of a practical asymmetric synthesis of a TRPV1 antagonist
Arjun Raghuraman
Dow Chemical
Sequential DMC/FAB-catalyzed alkoxylation towards high primary hydroxyl, high equivalent weight polyether polyols
Jackie Milne
Amgen
Development of a robust process for a cMet inhibitor
2015 Awardees
Gregg Keaney
H3 Biomedicine
Total synthesis of 6-deoxypladienolide D and assessment of splicing inhibitory activity in a mutant SF3B1 cancer cell line
Roy Helmy
Merck
Development and implementation of innovative high-throughput screening and analysis solutions to support discovery and development of active pharmaceutical ingredients in the pharmaceutical industry
Patricia Brieva
L’Oreal
Organic acid applications within the cosmeceutical industry “chemical peels”
Reema Thalji
GlaxoSmithKline
Structure-guided design and optimization of fluoroquinolone-substituted bacterial type IIA DNA topoisomerase inhibitors
Paul LaBeaume
Dow Chemical
Application of synthetic organic chemistry in the design of cationic initiators for next generation photoresists
Kevin Cole
Eli Lilly
Continuous processing: Chemical route development and GMP implementation
Timothy Briggs
Ensemble Therapeutics
DNA-programmed chemistry toward macrocycle libraries for drug discovery
Andrew Vetter
Eastman Chemical
Cobalt catalyzed reductive carbonylation of methanol
Andrew Hejl
Dow Chemical
Designed hybridization – acrylic-epoxy hybrid dispersions for industrial coating applications
Nathan Ide
Pfizer
Development of a commercial manufacturing process for Ibrance® (palbociclib)
Jeffrey Kallemeyn
AbbVie
Approaches to the heterocyclic core of Ilorasertib
Andrew Satterfield
DuPont
Carbonyl containing heterocycles as aromatic isosteres in 4-hydroxyphenylpyruvate dioxygenase (HPPD) herbicides
Antonella Converso
Merck
Discovery of adenosine analog inhibitors of S-adenosylhomocysteine hydrolase
Ke Chen
Bristol-Myers-Squibb
Overcoming steric and electronic obstacles: Development of efficient syntheses of active pharmaceutical ingredients
Martin Schnermann
National Cancer Institute
Near-IR uncaging chemistry: Discovery and applications
Sheng Cui
Amgen
Chiral chemistry for API synthesis
2014 Awardees
Nicole Knight
Dow Chemical
Multidisciplinary problem solving in industrial research
Anthony A Estrada
Genentech
Access to potent, selective, efficacious, and highly functionalized pyrimidoaminotropane mTOR inhibitors through the development of a flexible pyrimidine methodology
Christoph W Zapf
Pfizer
Lessons learned from targeting interleukin-2 inducible T cell kinase (ITK) by a covalent approach
Kelly M George
L’Oreal
Development of new skin care cleansing formulations using design of experiment and fast formulation tools
Beth M. Cooper
Dow Chemical
Latex-pigment interactions in paint to reduce environmental impact and improve performance
Rebecca T Ruck
Merck
MK-7655: Surprising synthetic complexity for seemingly straightforward steps
Adrian Ortiz
Bristol-Myers-Squibb
Discovery of an innovative stereoselective synthesis of BMS-986001: A nucleoside reverse transcriptase inhibitor (NRTI) for the treatment of HIV infection
Sébastien Lemaire
Janssen Pharmaceutica
Stereoselective C-glycosylation reactions with arylzinc reagents
Shashank Shekhar
AbbVie
Discovery of novel catalytic technologies in the process development of HCV polymerase inhibitors
Jared L. Piper
Eli Lilly
Process development and synthetic approaches for a CB1 inverse agonist
2013 Awardees
Santhosh F Neelamkavil
Merck
Discovery of bridged bicyclic piperidines as GPR119 agonists for the treatment of Type 2 diabetes
Kurt Hirsekorn
Dow Chemical
Selective methane activation and chlorocarbon development for climate friendly refrigerants via free radical chemistries
John S. Schneekloth
National Cancer Institute
Chemical probes of protein sumoylation: Strategies and tactics
David L. Gray
Pfizer
Medicinal chemistry at the blood-brain interface: Challenge and opportunity
Shawn D. Walker
Amgen
Development of new methods for the asymmetric synthesis of small molecule drug candidates
Allyn T. Londregan
Pfizer
Synthetic enablement for drug discovery: A new method for the addition of nucleophiles to pyridine-N-oxides
Owendi Ongayi
Dow Electronic Materials
Development of materials for semiconductor device fabrication
Rami Hannoush
Genentech
Peptides tools for targeting the zymogen form of a caspase
Artis Klapars
Merck
Asymmetric synthesis of complex drug targets
2012 Awardees
Michael T. Rudd
Merck
Discovery of vaniprevir (MK-7009) and MK-5172: Macrocyclic HCV NS3/4a protease inhibitors
Stephen M. Lynch
Hoffmann-La Roche
Design and synthesis of novel monoamine triple reuptake inhibitors
Jason S. Tedrow
Amgen
Route selection toward AMG 222: A direct tetrazole addition strategy toward building molecular complexity
Ming Xu
DuPont Crop Protection
Synthesis and crop protection utility of novel fused heterobicyclic isoxazolines
Ed Cleator
Merck
Discovery of an asymmetric synthesis of suvorexant
Lori Krim Gavrin
Pfizer
Adventures in medicinal chemistry: Drug design and probe design
2011 Awardees
Vincent Mascitti
Pfizer
Discovery of clinical candidate PF-04971729: An anti-diabetic agent from the structurally unique dioxa-bicyclo[3.2.1]octane class of SGLT2 inhibitors
Lisa A. Marcaurelle
Broad Institute
Diversity-oriented synthesis: From macrocyclesto spirocycles and beyond
Brian C. Shook
Johnson & Johnson
Indenopyrimidines as dual adenosine A2A/A1 antagonists for the treatment of Parkinson’s disease
Xing Dai
Merck
Example of drug discovery program leading to the development of novel reactions
Aaron T. Wright
Pacific Northwest National Laboratory
Identification of proteins relevant to bioenergy and disease pathology by chemical proteome profiling
Spencer D. Dreher
Merck
Collaboration and communication in chemistry
Ted W. Johnson
Pfizer
HIV integrase and the Golden Triangle: Overcoming synthetic challenges to compounds occupying unique chemical space
Martin D. Eastgate
Bristol-Myers Squibb
On the palladium catalyzed oxidation of cyclic dienes
2010 Awardees
Vassil I. Elitzin
GlaxoSmithKline
Efficient and practical synthesis of GSK812397, an HIV drug candidate
Qinhua Huang
Pfizer
Synthesis and evaluation of NO donor containing carbonic anhydrase inhibitors
Andrew W. Fraley
Ensemble Discovery
DNA-programmed chemistry approaches to macrocyclic lead compounds
Catherine A Faler
ExxonMobil Chemical Company
Synthesis of pyridyl amine ligands for catalyzed ethylene oligomerization
Robert D. Mazzola
Jr., Merck/Ligand Pharmaceuticals
Design and synthesis of novel ß-secretase (BACE) inhibitors
Hannah Yu
Eli Lilly
Development of an efficient palladium-catalyzed intramolecular carbometalation reaction for the synthesis of a dibenzoxapine-containing tetrasubstituted exocyclic alkene
Fa Liu
National Cancer Institute
Peptide mimetics disrupting protein-protein interactions discovered by post-solid phase modifications
Francis Gosselin
Merck
Asymmetric hydrogenation of unprotected N-H ketoimines
Nidhi Gupta
Biodesign Institute, Arizona State University
Synthetic ligands (synbodies): Syntheticalternatives to antibodies
Matthew M. Bio
Amgen
Practial arene metallation chemistry
2009 Awardees
Craig J. Thomas
National Institutes of Health
Bioactive small molecule discovery at the NIH chemical genomics center
David Tellers
Merck
Application of automation to synthetic organic challenges Shawn M. Dirk, Sandia National Laboratories
Development of novel polymeric capacitor dielectric materials
Development of novel polymeric capacitor dielectric materials
Xianhai Huang
Schering-Plough Research Institute
Total synthesis and SAR development of potent antitumor natural product psymberin/irciniastatin A
Andrew E. Taggi
DuPont Crop Protection
Chemistry at the interface of agriculture and medicine: Pyrazinones as tubulin modulators
Dafydd R. Owen
Pfizer
Enabling the hit to lead process at Pfizer: The value of organic synthesis
M. Uljana Mayer
Pacific Northwest National Laboratory
New probes for proteomics: Synthesis and application to problems in health and bioenergy
Karin M. Balss
Cordis Corporation
Investigation of chemical spatial distribution of drug and polymer in drug-eluting stent coatings
Stefan G. Koenig
Sepracor
Lessons learned: Development of a catalytic asymmetric hydrogenation process
Daniel H. Appella
National Institutes of Health
Molecular designs for peptide nucleic acids in detection and multivalent platforms
Eric Assen B. Kantchev
Forma Therapeutics Singapore
Rational exploration and exploitation of palladacycle diversity: Design and development of the SingaCycle family of NHC-palladacycle cross-coupling catalysts
Oliver Thiel
Amgen
Synthesis and process development of an advanced drug candidate
Jeffrey C. Gildersleeve
National Cancer Institute
Multidimensional carbohydrate microarrays for cancer research
2008 Awardees
Yue-Mei Zhang, Johnson & Johnson
Regioselective Pd-catalyzed coupling of halopyrimidines and synthesis of functionalized pyrimidoindole heterocycles
Shane W. Krska
Merck
Harnessing the power of high-throughput experimentation for catalytic reaction development at Merck
Percy H. Carter
Bristol-Myers Squibb
Discovery of potent, selective, and orally bioavailable antagonists of CC Chemokine Receptor 2
Florence Mehlmann
Arkema
Developments of new polymer architectures by controlled radical polymerization
Zhao-Kui Wan, Wyeth Research
Serendipitous synthetic discoveries: A tale of phosphonium and oxybenzotriazole chemistry
Daniel Steiger
General Electric Global Research
Rational design of surfaces with nanometer-sized domains for improved blood compatibility
Kanth V. B. Josyula
Aldrich Chemical Company
Enabling boron-based reagents in chemical synthesis: A story of advancing science through new product development at Aldrich
Brian A. Johns
GlaxoSmithKline
Novel synthetic methods to facilitate the pursuit of antiviral drugs
Erik J. Hembre
Eli Lilly
Discovery of the NK-1 antagonist LY686017
2007 Awardees
J. Kent Barbay
Johnson & Johnson
Synthesis and evaluation of small molecule C5a receptor antagonists
Kevin R. Campos
Merck
Enantioselective arylation of N-Boc pyrrolidine
Robert M. Borzilleri
Bristol-Myers Squibb
From cytotoxic agents to targeted therapies: A new era in oncology research
Robert A. Singer
Pfizer
Development of nonproprietary catalysts for the palladium-catalyzed amination reaction
Edmund I. Graziani
Wyeth Research
Synthesis and chemical biology of ILS-920: A novel non-immunosuppressive rapamycin analog with efficacy in multiple animal models of ischemic stroke