2022 Awardees

Kaid Harper
AbbVie
Carolyn Wei
Amgen
Martin Himmelbauer
Biogen
Emily Cherney
BMS
Maryll Geherty
BMS
John Roberts
Dow
Andrew DeAngelis
FMC
Allen Hong
Genetech
Terry Lebold
Janssen
Connor Martin
Janssen
Austin Smith
Loxo – Lilly
Yining Ji Chen
Merck
Eric Phillips
Merck
David Thaisrivongs
Merck
Janelle Sauvageau
NRC, Canada
Simone Bonazzi
Novartis
Hansnain Malik
Novartis
Dan Schmitt
Pfizer

2021 Awardees

Omar Ahmad
Blueprint
Christophe Allais
Pfizer
Matthew Beaver
Amgen
Raphaelle Berger
Merck
Alexander Buitrago-Santanilla
GSK
Ida Chen
Dow
Anne-Marie Dechert Schmitt
Pfizer
Amelie Dion
Merck/Pfizer
Anna Dunn
GSK
Candice Joe
BMS
Anais Jolit
AbbVie
Leo Joyce
Arrowhead
Carolyn Leverett
Pfizer
Xiaoli Liao
AbbVie
Brian Loy
Corteva Agriscience
Yu Lu
Lilly
Feng Peng
Merck
Vivek Rauniyar
Novartis
Chris Regens
Gilead
Troy Reynolds
AbbVie
Trevor Sherwood
BMS
Steven Silverman
Merck
Lauren Sirois
Genentech
Craig Stivala
Genentech
Shun Su
BMS
Benjamin Taft
Novartis
Dan Treitler
BMS
Tom Willumstad
Dow
Yun Zhang
AstraZeneca

2020 Awardees

Matthew Belowich
Dow

Lewis Acids as Highly Active Silanol Polycondensation Catalysts Affording Low Levels of Cyclosiloxanes

Tamas Benkovics
Merck

Innovation for the Synthesis of Diverse Nucleosides

Nick Desrosiers
Pfizer

Development of Difluoromethylation Methodologies for Large-Scale Processes

Anna Fryszkowska
Merck

Biocatalysis in the pharmaceutical industry – chemistry for tomorrow’s earth.

Chong Han
Genentech

Chemoselective, Stereocontrolled Cu-Catalyzed C-N Couplings Towards a Highly Potent mPI3Ka Inhibitor GDC-0077

Sebastien Monfette
Pfizer

Nickel catalysis: Novel ligands and reactions of practical importance to the pharmaceutical industry

Ryan Moslin
BMS

Inhibition of TYK2 via the Pseudokinase: The Discovery of Deucravacitinib

Jaclyn Murphy
DuPont

Development of new materials for electronic applications

Zack Oblak Oblak
GSK

The design and development of a manufacturing process for GSK’772

Martins Oderinde
BMS

Photocatalytic [2+2] Cycloaddition for Building Cyclobutane-Fused Three-Dimensional Molecular Complexity

Andrew Parsons
Amgen

Development of a commercial manufacturing process for an atropisomeric KRAS G12C inhibitor

Ryan Patman
Pfizer

Design and Synthesis of Carbonucleoside Inhibitors of PRMT5 for the Treatment of Cancer: A Desymmetrization Approach

David Pearson
Dow

Carbon-carbon centered radical initiators for polymerization of unsaturated monomers.

Christopher Plummer
Merck

Identification and Optimization of Positive Allosteric GPR40 Agonists for Diabetes

Danica Rankic
Pfizer

Strategies toward robust and scalable syntheses of α-pyrazolyl pyrrolidines

Mari Rosen
Dow

Chromium Catalysts with Phospholane Ligands for Ethylene Tetramerization

Janelle Steves
GSK

HTE in 3D: Implication of phosphine featurization methods on HTE design and analysis of reaction outcomes

Aimee Usera
Novartis

Ride of a lifetime: a novel half-life extension technology succeeding across chemical space

Jason Zbieg
Genentech

Discovery of a Chiral Amphiphilic Iridium Catalyst for Carbon- Heteroatom Bond Formation: Reactions of Amines, Anilines, Indoles and Other Various Nucleophiles.

2019 Awardees

Brad Bailey
Dow

Polyolefin catalysts for the production of ethylene-based fluids

Bryan Barton
Dow Dupont E&I

Shifting the oxidation pathways of polyethylene to provide carbonaceous species in high yield

Amanda Dombrowski
Abbvie

High-throughput reaction screening enabled by small scale solid dispensing

Shuzhi Dong
Merck

Discovery of MK-8153: ROMK inhibitor as new mechanism diuretic for hypertension and heart failure

Stephen Greszler
Abbvie

Impacting the pipeline through discovery synthesis groups: Cystic fibrosis, HCV, and immunology

Michael Harris
NovoNordisk

Development of PMC friendly approaches to the construction of synthetically challenging cyclopropane motifs

Josh Kaitz
Dupont

Rational design of organic materials for advanced microlithography

Jonrock Kong
Merck

Design and development of catalytic processes for the synthesis of antiviral agents EFdA (MK-8591) and vaniprevir (MK-7009)

Chad Lewis
Pfizer

Asymmetric atropisoinduction

David Marcoux
BMS

Rationally designed, conformationally constrained inverse agonists of ROR?t: Identification of a potent, selective series with biologic-like in vivo efficacy

Tricia May-Dracka
Biogen

Investigation of small molecule inhibitors of PLD for the treatment of ALS

Meredith McGowan
Merck

Discovery and evolution of potent and selective heme-displacing IDO1 inhibitors

Jordan Meier
NCI

New insights into acetylation & oncometabolism from chemoproteomics

Theo Michels
eFfector

Synthesis of bioactive flavagline analogues as inhibitors of cap-dependent translation: Discovery of eFT226

Erik Regalado
Merck

Universal chromatographic methods and fit for purpose workflows in the research and development of new pharmaceuticals

Benjamin Sherry
Merck

Process development in the pharmaceutical industry

Iulia Strambeau
GSK

Convergent synthesis of the NS5B inhibitor GSK8175 enabled by transition metal catalysis

Jenna Terebetski

Want to improve your (bio)performance? Take a closer look at the physical properties

Rubben Torella
Pfizer

Designing for bias: Computational methods to drive rational design of G-protein biased agonists

Joseph Tucker
Pfizer

High-throughput experimentation in flow: From screening to compound production

Steven Wisniewski
Bristol-Myers Squibb

Robust catalytic transformations: Value of mechanistic studies in process chemistry

Robert Wright
Dow

Organic molecules as forensic fuel markers

Ian Young
Genentech

Application of under-utilized transformations to the synthesis of pharmaceutically relevant molecules

2018 Awardees

Karla Bravo-Altamirano
Corteva Agriscience

Synthesis and bioactivity of carbohydrate-based macrocyclic picolinamide fungicides.

Alison Brewer
Pfizer

Design, development and scale-up of a homogeneous Chan-Lam coupling

Matthew Campbell
Merck

Herbicidal 2-aryl-1,2,3-triazoles

Benoit Cardinal-David
Abbvie

Flow chemistry: Impact on early process development

Chiol Chung
Genentech

Expedient synthesis of chiral tryptamines via a regioselective indole alkylation

Jamie McCabe Dunn
Merck

Vignettes in process chemistry spanning enabling discovery chemistry to manufacturing route development

Marie Gabrielle-Braun
Genentech

Discovery of GDC-0077: A highly selective inhibitor of PI3K-alpha that induces degradation of mutant-p110 alpha protein

Tom Greshock
Merck

Innovative chemistry enabling drug discovery: Leveraging new frontiers in organic synthesis to improve success rate

David Laitar
Dow

Boron- and copper-based TADF emitters: Synthesis, photochemical characterization and OLED device performance

Ricardo Lira
Pfizer

Preparation and optimization of macrocyclic peptide-like inhibitors for intravenous applications

Sheng Liu
Dow

Design and synthesis of high carbon content polymers via catalytic oxidative cross-coupling reactions for application in advanced manufacture

Michael Luzung
Bristol–Myers Squibb

Discovering innovative and impactful chemistry through external collaborations

Steven M. Mennen
Amgen

Integration of discovery and process development to deliver a high complexity BACE inhibitor

Joseph Pero
GlaxoSmithKline

Discovery of a novel class of TRPV4 antagonists and optimization with respect to LLE, oral PK properties and off-target activity

Angela Puchlopek-Dermenci
Pfizer

Commercial route development of a SMO inhibitor

Aaron Smith
Pfizer

Speed to clinic: The critical role of organic synthesis in medicinal chemistry.

2017 Awardees

Scott Bader
Pfizer

Synthesis of active pharmaceutical ingredients (APIs): Difficulties in the synthesis of the parts can be greater than that of the whole

Douglas Behenna
Pfizer

Discovery and early enablement of PF-06747775: A next generation irreversible inhibitor of mutant EGFR for the treatment of NSCLC.

Aaron Burns
Dart Neuroscience

Aldehyde Oxidase Metabolism in Drug Discovery

Vincent Chan
AbbVie

Development of a robust process for Venetoclax

Michael Demartino
GlaxoSmithKline

Next generation RET kinase inhibitor: Improved physicochemical and PK properties enhance local GI tissue distribution

Kevin Hesp
Pfizer

Synthesis of Photoreactive Chemical Probes through Late-Stage Heterocyclic C-H Functionalization of Unmodified Biologically Active Molecules

Xin Linghu
Genentech

Development of a practical synthesis of small molecule intermediate for THIOMAB-antibiotic conjugates (TACs)

Zhijian Liu
Merck

Asymmetric Hydrogen Bonding Catalysis for the Synthesis of Dihydroquinazoline-containing Antiviral, Letermovir

Ana Minatti
Amgen

Fueling the Alzheimer’s BACE1 Race with Genetic Insights and Cyclopropyloxazine BACE1 Inhibitors

Christian Nilewski
eFFECTOR Therapies

Design and synthesis of novel natural product-inspired eIF4A inhibitors

Thomas Pillow
Genentech

New Chemistries for Antibody-Drug Conjugates

Izzat Raheem
Merck

Discovery of 2-pyridinone aminals: A prodrug strategy to advance a second generation of HIV-1 integrase strand transfer inhibitors

Matthew Schiffler
Lilly

mPGES-1 Inhibitors from start to clinic

Eric Simmons
Bristol–Myers Squibb

Discovery, Development and Mechanistic Study of Catalytic Transformations for the Multi-Kilogram Scale Synthesis of Pharmaceutical Intermediates

Emile Velthuisen
GlaxoSmithKline

Design of Highly Potent Allosteric Integrase Inhibitors

Abbas Walji
Merck

New opportunities for synthetic chemistry to enable drug discovery: Discovery of [18F]MK-6240 a novel PET imaging agent for tau pathology

2016 Awardees

Robert Aversa
Novartis

ATR inhibitors for cancer: SBDD and mitigation of TDI

Haiming Zhang
Genentech

Practical processes to selective estrogen receptor degrader GDC-0810

Michael Schmidt
Bristol-Myers Squibb

Case studies in process research: Small molecules with big challenges

Hua Xu
Pfizer

Applications of sulfonyl fluorides in drug discovery and chemical biology

Erin P. Keaney
Novartis

Disruption of autophagy in vivo via selective Vps34 inhibitors

Eric C. Hansen
Pfizer

Mining pharmaceutical libraries for new ligands in nickel catalysis

Philip Fontaine
Dow Chemical

Discovery and development of molecular polyolefin catalysts

Hilary S. Eidam
GlaxoSmithKline

RET inhibitors for the treatment of irritable bowel syndrome

Christopher am Ende
Pfizer

Design and application of photoaffinity probes to investigate the mechanism of action of ?-secretase inhibitors and modulators

Joseph R. Martinelli
Eli Lilly

Evolution of a platform for aerobic processes

Malliga R. Iyer
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Synthetic approaches toward the design of multi-target compounds for the treatment of metabolic disorders and fibrosis

Anna V. Davis
Dow Chemical

Advances in the direct control of polyethylene oxide molecular weight

Mirlinda Biba
Merck

Chromatographic analysis and separation of short RNA oligonucleotides with novel liquid chromatography methods

Dennie S. Welch
AbbVie

Development of a practical asymmetric synthesis of a TRPV1 antagonist

Arjun Raghuraman
Dow Chemical

Sequential DMC/FAB-catalyzed alkoxylation towards high primary hydroxyl, high equivalent weight polyether polyols

Jackie Milne
Amgen

Development of a robust process for a cMet inhibitor

2015 Awardees

Gregg Keaney
H3 Biomedicine

Total synthesis of 6-deoxypladienolide D and assessment of splicing inhibitory activity in a mutant SF3B1 cancer cell line

Roy Helmy
Merck

Development and implementation of innovative high-throughput screening and analysis solutions to support discovery and development of active pharmaceutical ingredients in the pharmaceutical industry

Patricia Brieva
L’Oreal

Organic acid applications within the cosmeceutical industry “chemical peels”

Reema Thalji
GlaxoSmithKline

Structure-guided design and optimization of fluoroquinolone-substituted bacterial type IIA DNA topoisomerase inhibitors

Paul LaBeaume
Dow Chemical

Application of synthetic organic chemistry in the design of cationic initiators for next generation photoresists

Kevin Cole
Eli Lilly

Continuous processing: Chemical route development and GMP implementation

Timothy Briggs
Ensemble Therapeutics

DNA-programmed chemistry toward macrocycle libraries for drug discovery

Andrew Vetter
Eastman Chemical

Cobalt catalyzed reductive carbonylation of methanol

Andrew Hejl
Dow Chemical

Designed hybridization – acrylic-epoxy hybrid dispersions for industrial coating applications

Nathan Ide
Pfizer

Development of a commercial manufacturing process for Ibrance® (palbociclib)

Jeffrey Kallemeyn
AbbVie

Approaches to the heterocyclic core of Ilorasertib

Andrew Satterfield
DuPont

Carbonyl containing heterocycles as aromatic isosteres in 4-hydroxyphenylpyruvate dioxygenase (HPPD) herbicides

Antonella Converso
Merck

Discovery of adenosine analog inhibitors of S-adenosylhomocysteine hydrolase

Ke Chen
Bristol-Myers-Squibb

Overcoming steric and electronic obstacles: Development of efficient syntheses of active pharmaceutical ingredients

Martin Schnermann
National Cancer Institute

Near-IR uncaging chemistry: Discovery and applications

Sheng Cui
Amgen

Chiral chemistry for API synthesis

2014 Awardees

Nicole Knight
Dow Chemical

Multidisciplinary problem solving in industrial research

Anthony A Estrada
Genentech

Access to potent, selective, efficacious, and highly functionalized pyrimidoaminotropane mTOR inhibitors through the development of a flexible pyrimidine methodology

Christoph W Zapf
Pfizer

Lessons learned from targeting interleukin-2 inducible T cell kinase (ITK) by a covalent approach

Kelly M George
L’Oreal

Development of new skin care cleansing formulations using design of experiment and fast formulation tools

Beth M. Cooper
Dow Chemical

Latex-pigment interactions in paint to reduce environmental impact and improve performance

Rebecca T Ruck
Merck

MK-7655: Surprising synthetic complexity for seemingly straightforward steps

Adrian Ortiz
Bristol-Myers-Squibb

Discovery of an innovative stereoselective synthesis of BMS-986001: A nucleoside reverse transcriptase inhibitor (NRTI) for the treatment of HIV infection

Sébastien Lemaire
Janssen Pharmaceutica

Stereoselective C-glycosylation reactions with arylzinc reagents

Shashank Shekhar
AbbVie

Discovery of novel catalytic technologies in the process development of HCV polymerase inhibitors

Jared L. Piper
Eli Lilly

Process development and synthetic approaches for a CB1 inverse agonist

2013 Awardees

Santhosh F Neelamkavil
Merck

Discovery of bridged bicyclic piperidines as GPR119 agonists for the treatment of Type 2 diabetes

Kurt Hirsekorn
Dow Chemical

Selective methane activation and chlorocarbon development for climate friendly refrigerants via free radical chemistries

John S. Schneekloth
National Cancer Institute

Chemical probes of protein sumoylation: Strategies and tactics

David L. Gray
Pfizer

Medicinal chemistry at the blood-brain interface: Challenge and opportunity

Shawn D. Walker
Amgen

Development of new methods for the asymmetric synthesis of small molecule drug candidates

Allyn T. Londregan
Pfizer

Synthetic enablement for drug discovery: A new method for the addition of nucleophiles to pyridine-N-oxides

Owendi Ongayi
Dow Electronic Materials

Development of materials for semiconductor device fabrication

Rami Hannoush
Genentech

Peptides tools for targeting the zymogen form of a caspase

Artis Klapars
Merck

Asymmetric synthesis of complex drug targets

2012 Awardees

Michael T. Rudd
Merck

Discovery of vaniprevir (MK-7009) and MK-5172: Macrocyclic HCV NS3/4a protease inhibitors

Stephen M. Lynch
Hoffmann-La Roche

Design and synthesis of novel monoamine triple reuptake inhibitors

Jason S. Tedrow
Amgen

Route selection toward AMG 222: A direct tetrazole addition strategy toward building molecular complexity

Ming Xu
DuPont Crop Protection

Synthesis and crop protection utility of novel fused heterobicyclic isoxazolines

Ed Cleator
Merck

Discovery of an asymmetric synthesis of suvorexant

Lori Krim Gavrin
Pfizer

Adventures in medicinal chemistry: Drug design and probe design

2011 Awardees

Vincent Mascitti
Pfizer

Discovery of clinical candidate PF-04971729: An anti-diabetic agent from the structurally unique dioxa-bicyclo[3.2.1]octane class of SGLT2 inhibitors

Lisa A. Marcaurelle
Broad Institute

Diversity-oriented synthesis: From macrocyclesto spirocycles and beyond

Brian C. Shook
Johnson & Johnson

Indenopyrimidines as dual adenosine A2A/A1 antagonists for the treatment of Parkinson’s disease

Xing Dai
Merck

Example of drug discovery program leading to the development of novel reactions

Aaron T. Wright
Pacific Northwest National Laboratory

Identification of proteins relevant to bioenergy and disease pathology by chemical proteome profiling

Spencer D. Dreher
Merck

Collaboration and communication in chemistry

Ted W. Johnson
Pfizer

HIV integrase and the Golden Triangle: Overcoming synthetic challenges to compounds occupying unique chemical space

Martin D. Eastgate
Bristol-Myers Squibb

On the palladium catalyzed oxidation of cyclic dienes

2010 Awardees

Vassil I. Elitzin
GlaxoSmithKline

Efficient and practical synthesis of GSK812397, an HIV drug candidate

Qinhua Huang
Pfizer

Synthesis and evaluation of NO donor containing carbonic anhydrase inhibitors

Andrew W. Fraley
Ensemble Discovery

DNA-programmed chemistry approaches to macrocyclic lead compounds

Catherine A Faler
ExxonMobil Chemical Company

Synthesis of pyridyl amine ligands for catalyzed ethylene oligomerization

Robert D. Mazzola
Jr., Merck/Ligand Pharmaceuticals

Design and synthesis of novel ß-secretase (BACE) inhibitors

Hannah Yu
Eli Lilly

Development of an efficient palladium-catalyzed intramolecular carbometalation reaction for the synthesis of a dibenzoxapine-containing tetrasubstituted exocyclic alkene

Fa Liu
National Cancer Institute

Peptide mimetics disrupting protein-protein interactions discovered by post-solid phase modifications

Francis Gosselin
Merck

Asymmetric hydrogenation of unprotected N-H ketoimines

Nidhi Gupta
Biodesign Institute, Arizona State University

Synthetic ligands (synbodies): Syntheticalternatives to antibodies

Matthew M. Bio
Amgen

Practial arene metallation chemistry

2009 Awardees

Craig J. Thomas
National Institutes of Health

Bioactive small molecule discovery at the NIH chemical genomics center

David Tellers
Merck

Application of automation to synthetic organic challenges Shawn M. Dirk, Sandia National Laboratories
Development of novel polymeric capacitor dielectric materials

Xianhai Huang
Schering-Plough Research Institute

Total synthesis and SAR development of potent antitumor natural product psymberin/irciniastatin A

Andrew E. Taggi
DuPont Crop Protection

Chemistry at the interface of agriculture and medicine: Pyrazinones as tubulin modulators

Dafydd R. Owen
Pfizer

Enabling the hit to lead process at Pfizer: The value of organic synthesis

M. Uljana Mayer
Pacific Northwest National Laboratory

New probes for proteomics: Synthesis and application to problems in health and bioenergy

Karin M. Balss
Cordis Corporation

Investigation of chemical spatial distribution of drug and polymer in drug-eluting stent coatings

Stefan G. Koenig
Sepracor

Lessons learned: Development of a catalytic asymmetric hydrogenation process

Daniel H. Appella
National Institutes of Health

Molecular designs for peptide nucleic acids in detection and multivalent platforms

Eric Assen B. Kantchev
Forma Therapeutics Singapore

Rational exploration and exploitation of palladacycle diversity: Design and development of the SingaCycle family of NHC-palladacycle cross-coupling catalysts

Oliver Thiel
Amgen

Synthesis and process development of an advanced drug candidate

Jeffrey C. Gildersleeve
National Cancer Institute

Multidimensional carbohydrate microarrays for cancer research

2008 Awardees

Yue-Mei Zhang, Johnson & Johnson

Regioselective Pd-catalyzed coupling of halopyrimidines and synthesis of functionalized pyrimidoindole heterocycles

Shane W. Krska
Merck

Harnessing the power of high-throughput experimentation for catalytic reaction development at Merck

Percy H. Carter
Bristol-Myers Squibb

Discovery of potent, selective, and orally bioavailable antagonists of CC Chemokine Receptor 2

Florence Mehlmann
Arkema

Developments of new polymer architectures by controlled radical polymerization

Zhao-Kui Wan, Wyeth Research

Serendipitous synthetic discoveries: A tale of phosphonium and oxybenzotriazole chemistry

Daniel Steiger
General Electric Global Research

Rational design of surfaces with nanometer-sized domains for improved blood compatibility

Kanth V. B. Josyula
Aldrich Chemical Company

Enabling boron-based reagents in chemical synthesis: A story of advancing science through new product development at Aldrich

Brian A. Johns
GlaxoSmithKline

Novel synthetic methods to facilitate the pursuit of antiviral drugs

Erik J. Hembre
Eli Lilly

Discovery of the NK-1 antagonist LY686017

2007 Awardees

J. Kent Barbay
Johnson & Johnson

Synthesis and evaluation of small molecule C5a receptor antagonists

Kevin R. Campos
Merck

Enantioselective arylation of N-Boc pyrrolidine

Robert M. Borzilleri
Bristol-Myers Squibb

From cytotoxic agents to targeted therapies: A new era in oncology research

Robert A. Singer
Pfizer

Development of nonproprietary catalysts for the palladium-catalyzed amination reaction

Edmund I. Graziani
Wyeth Research

Synthesis and chemical biology of ILS-920: A novel non-immunosuppressive rapamycin analog with efficacy in multiple animal models of ischemic stroke