2025 Organic Reaction Championship

Round 1

Opens: Dec 10, 12:00 AM ET

Grignard Reaction

740 Votes

Friedel-Crafts Alkylation/Acylation

158 Votes

Diels-Alder Reaction

649 Votes

Aldol Condensation

219 Votes

Wittig Reaction

661 Votes

Claisen Condensation

167 Votes

Suzuki-Miyaura Coupling

607 Votes

Heck Reaction

188 Votes

Negishi Coupling

446 Votes

Stille Coupling

311 Votes

Hydroboration-Oxidation

351 Votes

Reduction with Metal Hydrides

424 Votes

Clemmensen Reduction

146 Votes

Wolff-Kishner Reduction

596 Votes

Rosenmund Reduction

84 Votes

Swern Oxidation

663 Votes

Williamson Ether Synthesis

308 Votes

Sandmeyer Reaction

435 Votes

Cannizzaro Reaction

162 Votes

Hofmann Rearrangement

566 Votes

Hell-Volhard-Zelinsky

402 Votes

Reimer-Tiemann Reaction

261 Votes

Fischer Indole Synthesis

600 Votes

Perkin Reaction

107 Votes

Benzoin Condensation

175 Votes

Beckmann Rearrangement

518 Votes

Olefin Metathesis

453 Votes

Click Chemistry (CuAAC)

319 Votes

Sharpless Asymmetric Epoxidation

497 Votes

Noyori Asymmetric Hydrogenation

217 Votes

Sonogashira Coupling

359 Votes

Mitsunobu Reaction

377 Votes

Round 2

Opens: Dec 12, 12:00 AM ET

Grignard Reaction

278 Votes

Diels-Alder Reaction

275 Votes

Wittig Reaction

200 Votes

Suzuki-Miyaura Coupling

325 Votes

Negishi Coupling

180 Votes

Reduction with Metal Hydrides

325 Votes

Wolff-Kishner Reduction

145 Votes

Swern Oxidation

353 Votes

Sandmeyer Reaction

213 Votes

Hofmann Rearrangement

261 Votes

Hell-Volhard-Zelinsky

102 Votes

Fischer Indole Synthesis

381 Votes

Beckmann Rearrangement

113 Votes

Olefin Metathesis

379 Votes

Sharpless Asymmetric Epoxidation

259 Votes

Mitsunobu Reaction

232 Votes

Quarter-Finals

Opens: Dec 14, 12:00 AM ET

Grignard Reaction

198 Votes

Suzuki-Miyaura Coupling

197 Votes

Reduction with Metal Hydrides

204 Votes

Swern Oxidation

173 Votes

Hofmann Rearrangement

135 Votes

Fischer Indole Synthesis

217 Votes

Olefin Metathesis

250 Votes

Sharpless Asymmetric Epoxidation

111 Votes

Semi-Finals

Opens: Dec 16, 12:00 AM ET

Grignard Reaction

262 Votes

Reduction with Metal Hydrides

91 Votes

Fischer Indole Synthesis

87 Votes

Olefin Metathesis

240 Votes

Finals

Opens: Dec 18, 12:00 AM ET

Grignard Reaction

94 Votes

Olefin Metathesis

86 Votes

Champion

Grignard Reaction