2025 Organic Reaction Championship
Round 1
Opens: Dec 10, 12:00 AM ET
#1Grignard Reaction
740 Votes
#2Friedel-Crafts Alkylation/Acylation
158 Votes
#3Diels-Alder Reaction
649 Votes
#4Aldol Condensation
219 Votes
#5Wittig Reaction
661 Votes
#6Claisen Condensation
167 Votes
#7Suzuki-Miyaura Coupling
607 Votes
#8Heck Reaction
188 Votes
#9Negishi Coupling
446 Votes
#10Stille Coupling
311 Votes
#11Hydroboration-Oxidation
351 Votes
#12Reduction with Metal Hydrides
424 Votes
#13Clemmensen Reduction
146 Votes
#14Wolff-Kishner Reduction
596 Votes
#15Rosenmund Reduction
84 Votes
#16Swern Oxidation
663 Votes
#17Williamson Ether Synthesis
308 Votes
#18Sandmeyer Reaction
435 Votes
#19Cannizzaro Reaction
162 Votes
#20Hofmann Rearrangement
566 Votes
#21Hell-Volhard-Zelinsky
402 Votes
#22Reimer-Tiemann Reaction
261 Votes
#23Fischer Indole Synthesis
600 Votes
#24Perkin Reaction
107 Votes
#25Benzoin Condensation
175 Votes
#26Beckmann Rearrangement
518 Votes
#27Olefin Metathesis
453 Votes
#28Click Chemistry (CuAAC)
319 Votes
#29Sharpless Asymmetric Epoxidation
497 Votes
#30Noyori Asymmetric Hydrogenation
217 Votes
#31Sonogashira Coupling
359 Votes
#32Mitsunobu Reaction
377 Votes
Round 2
Opens: Dec 12, 12:00 AM ET
Grignard Reaction
278 Votes
Diels-Alder Reaction
275 Votes
Wittig Reaction
200 Votes
Suzuki-Miyaura Coupling
325 Votes
Negishi Coupling
180 Votes
Reduction with Metal Hydrides
325 Votes
Wolff-Kishner Reduction
145 Votes
Swern Oxidation
353 Votes
Sandmeyer Reaction
213 Votes
Hofmann Rearrangement
261 Votes
Hell-Volhard-Zelinsky
102 Votes
Fischer Indole Synthesis
381 Votes
Beckmann Rearrangement
113 Votes
Olefin Metathesis
379 Votes
Sharpless Asymmetric Epoxidation
259 Votes
Mitsunobu Reaction
232 Votes
Quarter-Finals
Opens: Dec 14, 12:00 AM ET
Grignard Reaction
198 Votes
Suzuki-Miyaura Coupling
197 Votes
Reduction with Metal Hydrides
204 Votes
Swern Oxidation
173 Votes
Hofmann Rearrangement
135 Votes
Fischer Indole Synthesis
217 Votes
Olefin Metathesis
250 Votes
Sharpless Asymmetric Epoxidation
111 Votes
Semi-Finals
Opens: Dec 16, 12:00 AM ET
Grignard Reaction
262 Votes
Reduction with Metal Hydrides
91 Votes
Fischer Indole Synthesis
87 Votes
Olefin Metathesis
240 Votes
Finals
Opens: Dec 18, 12:00 AM ET
Grignard Reaction
94 Votes
Olefin Metathesis
86 Votes
Champion
Grignard Reaction
Champion