Green Chemistry

Green Chemistry is the active revision of chemical syntheses and processes to mitigate environmental footprint. Organic chemists are therefore essential for the success and implementation of Green Chemistry in industry. The following external resources and links are intended to foster Green Chemistry in the organic chemistry community. The external organizations provided herein are not endorsed by the DOC. Please Contact Us/Provide Feedback to improve the website or resources.

Green Chemistry Network:

The ACS Green Chemistry & Engineering Conference (GCE or GCANDE) is annually held in mid-june on the West Coast during even-numbered years or the East Coast (Virigina) during odd-numbered years. The GCANDE family has grown considerably over the past 24 conferences and has representation internationally for the Green Chemistry community.

The ACS Green Chemistry Institute (GCI) Pharmaceutical Roundtable epitomizes Green Chemistry by refining chemical syntheses in the pharmaceutical industry. An aligned goal of minimizing waste for less environmental impact and less financial loss inspires the diverse pharmaceutical collaboration to exchange synthetic knowledge.

Solvent Literature:

  • CHEM21’s selection guide of classical- and less classical-solvents Prat, D.; Wells, A.; Hayler, J.; Sneddon, H.; McElroy, C. R.; Abou-Shehada, S.; Dunn, P. J. Green Chem. 2016, 18, 288-296. (open access)
  • GSK: Updating and Further Expanding GSK’s Solvent Sustainability Guide Alder, C. M.; Hayler, J. D.; Henderson, R. K.; Redman, A. M.; Shukla, L.; Shuster, L. E.; Sneddon, H. F. Green Chem. 2016, DOI: 10.1039/C6GC00611F.
  • Pfizer: Green chemistry tools to influence a medicinal chemistry and research chemistry based organisation Alfonsi, K.; Colberg, J.; Dunn, P. J.; Fevig, T.; Jennings, S.; Johnson, T. A.; Kleine, H. P.; Knight, C.; Nagy, M. A.; Perry, D. A.; Stefaniak, M. Green Chem . 2008, 10, 31-36.
  • Sanofi’s Solvent Selection Guide: A Step Toward More Sustainable Processes Prat, D.; Pardigon, O.; Flemming, H.; Letestu, S.; Ducandas, V.; Isnard, P.; Guntrum, E.; Senac, T.; Ruisseau, S.; Cruciani, P.; Hosek, P. Org. Proc. Res. Dev . 2013, 17, 1517-1525.
  • AstraZeneca: Toward a More Holistic Framework for Solvent Selection Diorazio, L. J.; Hose, D. R. J.; Adlington, N. K. Org. Proc. Res. Dev. 2016, ASAP (open access)
  • NMR Chemical Shifts of Trace Impurities: Industrially Preferred Solvents Used in Process and Green Chemistry (peaks of residual solvents in 6 different NMR solvents) Babij, N. R.; McCusker, E. O.; Whiteker, G. T.; Canturk, B.; Choy, N.; Creemer, L. C.; De Amicis, C. V.; Hewlett, N. M.; Johnson, P. L.; Knobelsdorf, J. A.; Li, F.; Lorsbach, B. A.; Nugent, B. M.; Ryan, S. J.; Smith, M. R.; and Yang, Q. Org. Process Res. Dev., 2016, 20, 661-667. (open access)
  • Development of GSK’s NMR Guides – A tool to encourage the use of more sustainable solvents Gottlieb, H. E.; Graczyk-Millbrandt, G.; Inglis, G. A.; Nudelman, A.; Perez, D.; Qian, Y.; Shuster, L. E.; Sneddon, H. F.; Upton, R. J. Green Chem. 2016 DOI: 10.1039/C6GC00446F.
  • A convenient guide to help select replacement solvents for dichloromethane in chromatography Taygerly, J. P.; Miller, L. M.; Yee, A.; Peterson, E. A. Green Chem. 2012, 14, 3020-3025.
  • Replacement of dichloromethane within chromatographic purification: a guide to alternative solvents MacMillan, D. S; Murray, J.; Sneddon, H. F. ; Jamieson, C.; Watson, A. J. B. Green Chem. 2012, 14, 3016-3019.
  • Development of a tripartite solvent blend for sustainable chromatography Chardon, F. M.; Blaquiere, N.; Castanedo, G. M.; Koenig, S. G. Green Chem. 2014, 16, 4102-4105.
  • Free Green Chemistry MOOC – created by IMI CHEM21 consortium. Due to be launched on 13 th June – but the test version is available to view here: http://test-chem21-elearning.pantheon.io/ . Pharmaceutical Green Chemistry is biased although the information is generalizable to other disciplines or industries

Reagent Guides:

  • ACS: Green Chemistry Institute’s Pharmaceutical Roundtable
  • Development of GSK’s Reagent Guides – Embedding Sustainability into Reagent Selection Adams, J. P.; Alder, C. M.; Bullion, A. M.; Campbell-Crawford, M.; Darcy, M. G.; Hayler, J. D.; Henderson, R. K.; Oare, C. A.; Pendrak, I.; Redman, A. M.; Shuster, L. E.; Sneddon, H. F.; Walker, M. D. Green Chem. 2013, 15, 1542-1549 .
  • Development of GSK’s Acid and Base Selection Guides Henderson, R. K.; Hill, A. P.; Redman, A. M.; Sneddon, H. F. Green Chem. 2015, 17, 945-949.
  • Evaluation of Alternative Solvents in Common Amide Coupling Reactions: Replacement of Dichloromethane and N, N -Dimethylformamide MacMillan, D. S.; Murray, J.; Sneddon, H. F.; Jamieson, C.; Watson, A. J. B. Green Chem. 2013, 15, 596-600 (open access).
  • Development of a Solvent Selection Guide for Aldehyde-based Direct Reductive Amination Processes McGonagle, F. I.; MacMillan, D. S.; Murray, J.; Sneddon, H. F.; Jamieson, C.; Watson, A. J. B. Green Chem. 2013, 15, 1159-1165.

General Resources: