JOC 2018 Publication of the Year Lectureship Award
Masayuki Inoue, Wins the 2018 The Journal of Organic Chemistry Outstanding Publication of the Year Lectureship Award
Masayuki Inoue, Chemistry Professor at the University of Tokyo, is the 2018 recipient of The Journal of Organic Chemistry Outstanding Publication of the Year Lectureship. The Journal of Organic Chemistry and the ACS Division of Organic Chemistry sponsor this annual award, which honors the author of an outstanding article published in the previous calendar year that demonstrates creativity and impact in the field of organic chemistry.
Inoue, who is also a JOC Associate Editor, was selected for this award because of the work his group did in synthesizing the antibiotic WAP-8294A2, known as lotilibcin, and describing how it works to wipe out the drug-resistant “superbug” MRSA (methicillin-resistant Staphylococcus aureus), which they reported in the article “Total Synthesis and Biological Mode of Action of WAP-8294A2: A Menaquinone-Targeting Antibiotic.” WAP-8294A2 was isolated from a soil sample and first reported in a Journal of the American Chemical Society paper “WAP-8294A2, A Novel Anti-MRSA Antibiotic Produced by Lysobacter sp.” in 1997. Because it’s very effective against MRSA, it is being developed as a potential new drug.
“We are delighted to celebrate this superb paper by Professor Inoue’s group describing detailed studies of both the total synthesis of a highly complex, macrocyclic peptidic antibiotic and related analogs, as well as function-oriented studies unveiling aspects of the compound’s profound biological activity,” says The Journal of Organic Chemistry Editor-in-Chief Scott J. Miller.