Organic Letters 2016 Outstanding Publication of the Year Lectureship Award
Dr. Lipshutz’s article describes the use of small quantities of a nonionic surfactant that enables nucleophilic aromatic substitution by oxygen-, nitrogen-, and sulfur-based nucleophiles at ambient temperatures in water. Comparing micellar and traditional conditions in the preparation of important drug intermediates emphasized the importance of this method, as the reactions proceed at much lower temperatures and products can be readily extracted directly from the reaction flask. This strategy may find broad application in industry, as it greatly reduces the dependence on organic solvents, especially commonly used DMF, leading to minimal waste production.
View the Outstanding Article:
- Nucleophilic Aromatic Substitution Reactions in Water Enabled by Micellar Catalysis
Nicholas A. Isley, Roscoe T. H. Linstadt, Sean M. Kelly, Fabrice Gallou, and Bruce H. Lipshutz