Organic Letters 2016 Outstanding Publication of the Year Lectureship Award

ACS Publications

Bruce Lipshutz Wins 2016 Organic Letters Outstanding Publication of the Year Lectureship Award

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The ACS Division of Organic Chemistry and Organic Letters are proud to announce Bruce Lipshutz, University of California, Santa Barbara, as the winner of the 2016 Organic Letters Outstanding Publication of the Year Lectureship Award. Dr. Lipshutz was nominated for his work on nucleophilic aromatic substitution reactions under aqueous micellar conditions. Dr. Lipshutz will be presented with an award at a symposium in his honor at the fall ACS National Meeting, August 21, 2016 in Philadelphia, Pennsylvania.

Dr. Lipshutz’s article describes the use of small quantities of a nonionic surfactant that enables nucleophilic aromatic substitution by oxygen-, nitrogen-, and sulfur-based nucleophiles at ambient temperatures in water. Comparing micellar and traditional conditions in the preparation of important drug intermediates emphasized the importance of this method, as the reactions proceed at much lower temperatures and products can be readily extracted directly from the reaction flask. This strategy may find broad application in industry, as it greatly reduces the dependence on organic solvents, especially commonly used DMF, leading to minimal waste production.

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